Home About Us Services Relevant Links Contact Us
Model
•
Sub-cutaneous Implantation

Basics
•
Test materials compared to standards & competitor materials
•
Surface photography of implantation sites at regular intervals
•
Implant site assessed at various time points after implantation
•
Gross inspection & documentation (e.g. photography) of implant sites
•
Histological/biochemical assessment to determine bio-compatibility & bio-degradability
•
Documentation of adverse/unexpected events through the study
•
Study period – up to a maximum of 12 months

Assessments
Bio-Compatibility - assessment of the tissue response to the presence of the implant and/or  any degradation products – in terms of:-  

v
  extent & duration of the inflammatory response
v
  extent & form of cellular ingress
v
  extent of foreign body reaction development
v
  extent of peri-implant fibrous encapsulation    

biocompatibility histology















Bio-Degradability - assessed in terms of the amount of implant material remaining with time after implantation. Determined from gross and/or histological images
biocompatibility biocompatibility
No response to product A
Significant response to product B
Applications
•
Widely used bio-medical model

•
Valuable performance & safety data

•
Bio-compatibility and longevity of products/scaffolds

•
The impact of inadvertent entrapment of dressing materials in wounds
Navigation
Pre-clinical research -Bio-Compatibility & Bio-Degradation
Wound Healing Models Physical Testing Protease Regulation / Modulation Anti-Microbial Efficacy Testing Haemostat Assessment Bio-compatibility / degradation
Back