Rate of Wound Closure

The impact of agents on wound closure is assessed using excisional wound models. Wound closure, which is measured by computer-assisted planimetry from calibrated images taken at intervals during the study, can be differentiated into its components:- Wound Re-epithelialisation & Wound Contraction (see below)

Original wound area

Area closed by contraction

Healing Wound

Area closed by re-epithelialisation

Open wound area remaining

Data showing % wound area remaining (relative to the original wound area on day 0) ± s.e.m. for a diabetes-impaired wound healing model .

The components of wound closure (% wound re-epithelialisation and % wound contraction) are also displayed, demonstrating a reduced ability of wound closure by contraction in diabetes-impaired wounds accompanied by a slight increase in wound closure by re-epithelialisation.

Treatment with a growth factor combination therapy (positive control) demonstrates a positive modulation of both components .

Wound Planimetry

Diagram showing wound planimetry measurements in a normal wound healing model.

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