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We are licensed to undertake studies in a range of experimental model systems that are widely used in wound healing research.


The majority of our pre-clinical work centres around the investigation of “agents” in terms of their impact on the repair of incisional & excisional surgical wounds under both ‘normal’, compromised (diabetes-impaired) and infected conditions.


Using these models we are able to examine the ability of agents to modulate (improve or impair) the wound healing process and also investigate the physical performance of wound management devices (exudate management, wound site adherence, tissue viability).


Assessments  
 The impact of investigational agents / therapies on wound healing can be assessed using a variety of measurement parameters and endpoints.
The following clinically relevant parameters are routinely assessed:
wound healing models
Normal Wounds
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Incisional or excisional
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Partial or full thickness
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Application/re-application of agents/devices under test
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Calibrated digital photography for wound closure planimetry
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Performance assessment:- exudate management, wound site adherence/ ease of removal, dressing integrity, dressing debris deposition
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Histological and biochemical assessment
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Up to 12 month study
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Detailed data analysis, statistical testing, digital imagery & report provision.
diabetes impaired wound healing model
Diabetes-impaired Wounds
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Obese & diabetic (type II)
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Full thickness excisional
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Delayed wound closure & impaired granulation tissue formation
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Used to investigate the ability of drugs/devices to accelerate the wound healing process.
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Calibrated digital photography for wound closure planimetry
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Histological and biochemical assessment
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Up to 1 month study
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Detailed data analysis, statistical testing, digital imagery & report provision.
Infected wound model
Infected Wound Models
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Full thickness excisional wounds
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Mono-microbial (S.aureus/P.aeruginosa) inoculation
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Establishment of infection based on CFU count and clinical signs
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Application/re-application of agents/devices under test or controls
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Calibrated digital photography for wound closure planimetry
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Assessment of infection level and wound closure over time
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Determination of Log kill
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Histological and biochemical assessment of wound
pre-clinical wound healing research
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Wound Healing Models Physical Testing Protease Regulation / Modulation Anti-Microbial Efficacy Testing Haemostat Assessment Bio-compatibility / degradation

Pre-clinical Research - Wound Healing Models


Rate of Wound Closure Wound Colour Profile Histological Assessments Tensiometry
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Further information on wound healing models is available on request